MO Juan, WU Jing, SUN Zh ixiang, YANG H aobo, LE IM inxiang, LIU W eifang

Release time:2016-05-06

Affiliation of Author(s):D ep ar t m ent of Endocrinology, X iangya H osp ital, Cen tral Sou th U niver sity

Teaching and Research Group:D ep ar t m ent of Endocrinology, X iangya H osp i

Journal:Journal of Central South University

Place of Publication:China

Funded by:unanProvincialEducationSciencePlanningProjectofChina(XJK 03AJ006)andNatural ScienceFoundationofHunan

Key Words:ch ildren; obesity; protein tyrosine phosphatase 1B; single nucleotide polym or
phism; leptin; insu

Abstract:Objective To investigate the distribu tion characteristics of protein tyrosine phospha
tase 1B (PTP1B ) gene IVS6 + G82A and P ro303P ro polym orphism s in Chinese children and determ ine th e effect ofPTP1B gene IVS6 + G82A and P ro303P ro polym orph ism s on the pathogenesis of ch ildhood ob esity. M ethods A total of 147 Ch inese obese and 118 healthy ch ildren w ere random ly selected and enrolled to identify IVS6 + G82A and Pro303Pro genotypes by polym erase chain reaction
restriction frag
m ent length polym orph ism ( PCR
RFLP) assay. W aist circum ference (W C), w aist to hip ratio (W

Co-author:莫娟； 吴静； 孙志香； 杨浩波； 雷闽湘； 刘玮芳

Indexed by:Applied Research

Document Code:10. 3969/j.issn. 1672-7347. 2010. 09. 003

Discipline:临床医学

Document Type:J

Volume:35

Issue:9

Page Number:915-920

ISSN No.:1672-7347

Translation or Not:no

Date of Publication:2009-12-18

Links to published journals:http://www.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&dbcode=CJFQ&dbname=CJFD2010&filename=HNYD201009004&urlid=&yx=&uid=WEEvREcwSlJHSldSdnQ1ZThyUWFyb283azRPcnYvaUhMUXNZR3pncWRZbjFQSVI3a2NBeVV