Plasma metabolic profiling of childhood obesity by GC/MS in conjunction with multivariate statistical analysis

Release time:2016-05-23

Affiliation of Author(s):Central South University

Teaching and Research Group:Research Center of Modernization of Chinese Herba

Journal:J Pharm Biomed Anal.

Place of Publication:china

Funded by:International Traditional Chinese Medicine Program for Cooperation in Science and Technol-ogy

Key Words:Canonical correlation analysis Childhood obesity Gas chromatography/mass spectrometry Metabolic fing

Abstract:Abstract Metabolic fingerprinting is a powerful tool for exploring systemic metabolic perturbations and potential biomarkers, thus may shed light on the pathophysiological mechanism of diseases. In this work, a new strategy of metabolic fingerprinting was proposed to exploit the disturbances of metabolic patterns and biomarker candidates of childhood obesity. Plasma samples from children with normal weight, overweight and obesity were first profiled by GC/MS. ULDA (uncorrelated linear discriminant analysis) then revealed that the metabolic patterns of the three groups were different.……

Indexed by:Unit Twenty Basic Research

Document Code:doi: 10.1016/j.jpba.2010.01.002.

Discipline:基础医学

Document Type:J

Volume:52

Issue:2

Page Number:265-72

ISSN No.:doi: 10.1016/j.jpba.2010.01.002.

Translation or Not:no

Date of Publication:2010-11-11

Links to published journals:http://www.ncbi.nlm.nih.gov/pubmed/?term=Plasma+metabolic+profiling+of+childhood+obesity+by+GC%2FMS+in+conjunction+with+multivariate+statistical+analysis