Association analysis of SLC30A8 rs13266634 and rs16889462 polymorphisms with type 2 diabetes mellitus and repaglinide response in Chinese patients.

Release time:2016-05-23

Affiliation of Author(s):Central South University

Teaching and Research Group:Institute of Clinical Pharmacology

Journal:Eur J Clin Pharmacol.

Place of Publication:Europe

Funded by:he National “created a major new drugs”-Science and Technology Major Project (No. 2009ZX09304)

Key Words:SLC30A8 rs13266634 . SLC30A8 rs16889462 . Genetic polymorphisms . Type 2 diabetes mellitus . Repagli

Abstract:Abstract OBJECTIVE: Genome-wide association studies (GWASs) identified that SLC30A8 genetic polymorphism was a risk of type 2 diabetes mellitus (T2DM) in several populations. This study aimed to investigate whether the SLC30A8 rs13266634 and rs16889462 polymorphisms were associated with T2DM susceptibility and repaglinide therapeutic efficacy in Chinese T2DM patients. METHODS: We conducted a case-control study of 443 T2DM patients and 229 healthy volunteers to identify SLC30A8 rs13266634 and rs16889462 genotypes by polymerase chain reaction-restriction fragment length polymorphism ……

Co-author:Liu ZQ., Zhou HH, Gong ZC, Yu M, Deng CS, Chen X, Wu J, Dai XP, Yin JY, Huang Q1

Indexed by:Unit Twenty Basic Research

Document Code:doi: 10.1007/s00228-010-0882-6.

Discipline:临床医学

Document Type:J

Volume:66

Issue:12

Page Number:1207–1215

ISSN No.:doi: 10.1007/s00228-010-0882-6.

Translation or Not:no

Date of Publication:2010-08-31

Links to published journals:http://www.ncbi.nlm.nih.gov/pubmed/?term=Association+analysis+of+SLC30A8+rs13266634+and+rs16889462+polymorphisms+with+type+2+diabetes+mellitus+and+repaglinide+response+in+Chinese+patients.