NAMPT -3186C ⁄ T polymorphism affects repaglinide response in Chinese patients with Type 2 diabetes mellitus

Release time:2016-05-23

Affiliation of Author(s):Central South University

Teaching and Research Group:Institute of Clinical Pharmacol- ogy

Journal:Clinical and Experimental Pharmacology and Physiol

Funded by:National High-tech R&D Program of 11. China (863 Program; 2009AA022703)

Key Words:efficacy, nicotinamide phosphoribosyltransferase, polymorphism, repaglinide, Type 2 diabetes.

Abstract:Abstract 1. In the present study, we investigated the associations of nicotinamide phosphoribosyltransferase (NAMPT)-3186 C/T and -948G/T polymorphisms with the risk of Type 2 diabetes mellitus (T2DM) and their impact on the efficacy of repaglinide in Chinese Han T2DM patients. 2. In all, 170 patients with T2DM and 129 healthy controls were genotyped for NAMPT-948G>T and -3186C>T polymorphisms. Thirty-five patients with different NAMPT -3186 C/T genotypes and the same organic anion-transporting polypeptide 1B1 (OATP1B1521) T/C genotype were randomly selected to undergo 8 weeks preprandial ……

Indexed by:Unit Twenty Basic Research

Document Code:doi: 10.1111/j.1440-1681.2011.05548.x.

Discipline:基础医学

Volume:38

Issue:8

Page Number:550-4

ISSN No.:doi: 10.1111/j.1440-1681.2011.05548.x.

Translation or Not:no

Date of Publication:2011-03-26

Links to published journals:http://www.ncbi.nlm.nih.gov/pubmed/?term=NAMPT+-3186C+%E2%81%84+T+polymorphism+affects+repaglinide+response+in+Chinese+patients+with+Type+2+diabetes+mellitus