KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) polymorphisms affect therapeutic efficacy of repaglinide in Chinese patients with type 2 diabetes

Release time:2016-05-23

Affiliation of Author(s):central South University

Teaching and Research Group:institute of clinical Pharmacology,

Journal:Clin Pharmacol Ther.

Funded by:National Major Project of Science and Technology of china grant 2009ZX09304,

Abstract:Abstract This study showed that the polymorphisms KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) are associated with a heightened risk of developing type 2 diabetes mellitus (T2DM). We also explored the effects of these polymorphisms on the efficacy of repaglinide therapy in Chinese patients with T2DM. A total of 259 patients with T2DM and 188 healthy controls were genotyped. Forty patients with various genotypes were randomly selected to undergo an 8-week repaglinide treatment regimen. Patients with the G allele of the KCNJ11 Lys23Glu polymorphism showed higher levels of fasting plasma glucose ……

Indexed by:Unit Twenty Basic Research

Document Code:doi: 10.1038/clpt.2009.242.

Discipline:基础医学

Document Type:J

Volume:87

Issue:3

Page Number:330-5.

ISSN No.:doi: 10.1038/clpt.2009.242.

Translation or Not:no

Date of Publication:2009-10-14

Links to published journals:http://www.ncbi.nlm.nih.gov/pubmed/?term=KCNJ11+Lys23Glu+and+TCF7L2+rs290487(C%2FT)+polymorphisms+affect+therapeutic+efficacy+of+repaglinide+in+Chinese+patients+with+type+2+diabetes