Tau pathology in diabetes mellitus

Release time:2016-05-23

Affiliation of Author(s):Central South University

Teaching and Research Group:Department of Pharmaceutical Engineering

Journal:Die Pharmazie

Place of Publication:Germany

Funded by:he Open-End Fund for the Valuable and Precision Instruments of Central South University

Key Words:Animals Humans Diabetic Neuropathies Tauopathies Phosphoric Monoester Hydrolases / Insulin /

Abstract:Neurodegenerative tauopathy characterized by hyperphosphorylation tau has been implicated in the pathophysiology of diabetic central nervous system (CNS) complication. Emerging evidence has suggested that hyperphosphorylation tau is caused by an imbalance of protein kinase and phosphatase activity. This review focuses on the contributions of impaired insulin signaling to diabetes-related tauopathy through disrupting the balance of tau-related protein kinases and phosphatases. In addition, we describe tau pathology as a potential target for central neuronal degeneration in diabetes mellitus.

Indexed by:Unit Twenty Basic Research

Document Code:doi: 10.1691/ph.2013.2901

Discipline:基础医学

Document Type:J

Page Number:649–652

ISSN No.:doi: 10.1691/ph.2013.2901

Translation or Not:no

Date of Publication:2012-12-28

Links to published journals:http://xueshu.baidu.com/s?wd=paperuri:(7dbd8b8a0609ab41f0f992fd3f509641)&filter=sc_long_sign&sc_ks_para=q%3DTau+pathology+in+diabetes+mellitus.&tn=SE_baiduxueshu_c1gjeupa&ie=utf-8