Dysregulated mTOR-Dependent Signaling in Neurodegeneration or Carcinogenesis:Implication for Alzheimer’s Disease and Brain Tumors.J Alzheimers Dis.

Release time:2016-05-23

Affiliation of Author(s):Central South University

Teaching and Research Group:Department of Endocrinology,

Journal:J Alzheimers Dis.

Funded by:National Natu- ral Science Foundation of China (No. 81170754 and 81001107).

Key Words:Alzheimer’s disease, carcinogenesis, mTOR, neurodegeneration

Abstract:Abstract Recent evidence implicated aberrant mammalian target of rapamycin (mTOR)-dependent signaling in both Alzheimer's disease (AD) and brain tumors. This review focuses on the potential mechanisms shared by both neurodegeneration and carcinogenesis. In particular, attention was paid to the possible roles of mTOR-dependent signaling in these two fundamental pathophysiological processes. We hypothesize that common stresses could lead either to progressive degeneration or uncontrolled carcinogenesis via cell type specific upregulation of mTOR-dependent signaling in the central nervous system

Indexed by:Unit Twenty Basic Research

Document Code:doi: 10.3233/JAD-130641.

Discipline:基础医学

Document Type:J

Volume:37

Issue:3

Page Number:495-505

ISSN No.:1387-2877/13/$27.50 ？ 2013

Translation or Not:no

Date of Publication:2013-06-14

Links to published journals:http://www.ncbi.nlm.nih.gov/pubmed/?term=Dysregulated+mTOR-Dependent+Signaling+in+Neurodegeneration+or+Carcinogenesis%3AImplication+for+Alzheimer%E2%80%99s+Disease+and+Brain+Tumors.J+Alzheimers+Dis.