nflammation-induced microvascular insulin resistance is an early event in diet-induced obesity

Release time:2016-05-23

Affiliation of Author(s):University of Virginia Health System

Teaching and Research Group:Division of Endocrinology and Metabolism

Journal:Clin Sci (Lond).

Funded by:the American Diabetes Association [grant numbers 1-11-CR-30 and 1-15-CE-32 (to Z.L.)]

Key Words:endothelial dysfunction; high-fat diet; inflammation; insulin resistance; muscle microvasculature; o

Abstract:Abstract Endothelial dysfunction and vascular insulin resistance usually coexist and chronic inflammation engenders both. In the present study, we investigate the temporal relationship between vascular insulin resistance and metabolic insulin resistance. We assessed insulin responses in all arterial segments, including aorta, distal saphenous artery and the microvasculature, as well as the metabolic insulin responses in muscle in rats fed on a high-fat diet (HFD) for various durations ranging from 3 days to 4 weeks with or without sodium salicylate treatment. Compared with controls……

Indexed by:Unit Twenty Basic Research

Document Code:doi: 10.1042/CS20150143.

Discipline:基础医学

Document Type:J

Volume:129

Issue:12

Page Number:1025-36

ISSN No.:doi: 10.1042/CS20150143.

Translation or Not:no

Date of Publication:2015-08-11

Links to published journals:http://www.ncbi.nlm.nih.gov/pubmed/?term=nflammation-induced+microvascular+insulin+resistance+is+an+early+event+in+diet-induced+obesity