Globular adiponectin ameliorates metabolic insulin resistance via AMPK-mediated restoration of microvascular insulin responses.

Release time:2016-05-23

Affiliation of Author(s):University of Virginia Health System

Teaching and Research Group:Division of Endocrinology and Metabolism

Journal:J Physiol.

Funded by:American Diabetes Association grants 1-11-CR-30 and 1-15-CE-32 (to Z.L.), and National Institutes of

Abstract:Abstract Adiponectin is an adipokine with anti-inflammatory and anti-diabetic properties. Hypoadiponectinaemia is closely associated with endothelial dysfunction and insulin resistance in obesity and diabetes. Insulin resistance is present in muscle microvasculature and this may contribute to decreased insulin delivery to, and action in, muscle. In this study we examined whether adiponectin ameliorates metabolic insulin resistance by affecting muscle microvascular recruitment. We demonstrated that a high-fat diet induces vascular adiponectin and insulin resistance but globular adiponectin ……

Indexed by:Unit Twenty Basic Research

Document Code:DOI: 10.1113/JP270371

Discipline:基础医学

Document Type:J

Volume:593

Issue:17

Page Number:4067-79

ISSN No.:doi: 10.1113/JP270371

Translation or Not:no

Date of Publication:2014-03-30

Links to published journals:http://www.ncbi.nlm.nih.gov/pubmed/?term=Globular+adiponectin+ameliorates+metabolic+insulin+resistance+via+AMPK-mediated+restoration+of+microvascular+insulin+responses