Professor
Supervisor of Doctorate Candidates
Supervisor of Master's Candidates
Main positions:1. Instructor of the "Talent Program" of the Chinese Ministry of Education and the China Association for Science and Technology2. Specially appointed expert of Hunan Overseas Chinese Federation3. "Optics" ， editorial board4. Member of American Physical Society, American Society of Electrical and Electronics Engineers, American Chemical Society, Royal Society of Chemistry.
Hits:
Impact Factor:12.95
DOI number:10.1007/s40820-021-00653-z
Affiliation of Author(s):中南大学
Journal:Nano-Micro Letters,
Abstract:Fluorescence lifetime imaging microscopy (FLIM) has been rapidly developed over the past 30 years and widely applied in biomedical engineering. Recent progress in fluorophore-dyed probe design has widened the application prospects of fluorescence. Because fluorescence lifetime is sensitive to microenvironments and molecule alterations, FLIM is promising for the detection of pathological conditions. Current cancer-related FLIM applications can be divided into three main categories: (i) FLIM with autofluorescence molecules in or out of a cell, especially with reduced form of nicotinamide adenine dinucleotide (NADH), and flavin adenine dinucleotide (FAD) for cellular metabolism research; (ii) FLIM with Förster resonance energy transfer for monitoring protein interactions; and (ⅲ) FLIM with fluorophore-dyed probes for specific aberration detection. Advancements in nanomaterial production and efficient calculation systems, as well as novel cancer biomarker discoveries, have promoted FLIM optimization, offering more opportunities for medical research and applications to cancer diagnosis and treatment. This review summarizes cutting-edge researches from 2015 to 2020 on cancer-related FLIM applications and the potential of FLIM for future cancer diagnosis methods and anti-cancer therapy development. We also highlight current challenges and provide perspectives for further investigation.
Indexed by:Journal paper
Correspondence Author:Yuzhen Ouyang, YP. Liu(刘艳平) *; Zhiming M. Wang, Zongwen Liu & Minghua Wu,*
Discipline:Natural Science
First-Level Discipline:Physics
Document Type:J
Volume:13
Issue:133
Translation or Not:no
Date of Publication:2021-06-10
Included Journals:SCI、SSCI
Links to published journals:https://link.springer.com/article/10.1007/s40820-021-00653-z
