Regulation of cellular iron metabolism and its implications in lung cancer progression
发布时间：2016-04-25
点击次数：
发表刊物：Medical oncology
摘要：Iron is essential for life and is involved in numerous metabolic processes including cell growth and proliferation. However, excess iron in the body raises the risk of developing cancer due to its capacity to engage in redox cycling and free radical production. Therefore, iron can contribute to both carcinogenesis and tumor growth. Both epidemiologic and laboratory studies have demonstrated that the effects of iron overload are associated with the tumorigenesis of lung cancer and growth of lung cancer cells. In particular, the discovery of hepcidin and several iron transporters in the past
备注：decade may warrant reconsideration of the role of iron in carcinogenesis and tumor cell proliferation in lung cancer. Pathways of iron uptake, storage, efflux, and regulation are all disturbed in cancer, suggesting that reprogramming of iron metabolism is a critical aspect of tumor cell survival.
合写作者：F., L.; Yu, W.; Wang, Xiong
论文类型：基础研究
学科门类：临床医学
文献类型：J
期号：2014, 31 (7),
页面范围：28
是否译文：否