Roles of the hepcidin-ferroportin axis and iron in cancer
发布时间：2016-04-25
点击次数：
发表刊物：European journal of cancer prevention
摘要：Hepcidin is a low-molecular-weight hepatic peptide that regulates iron homeostasis, and acts by causing the degradation of its receptor, the cellular iron exporter ferroportin. On the basis of the major role of the hepcidin-ferroportin axis in iron regulation, recently several studies have discussed its expression and influence on the development and prognosis of cancer. Iron plays a pivotal role in homeostasis. However, insights into the mechanisms of normal iron regulation have provided a new perspective on the basic mechanisms, biological rationale, and pathophysiologic implications of
备注：changes in iron metabolism in cancer. Besides being a crucial stimulus for cancer, iron dysfunction also causes cancer-related anemia. In this review, we discuss aspects of the hepcidin-ferroportin axis and iron regulation, as well as the inherent connections between them in cancer. We also attempt to consider the possibility in theory of novel targets for further individualized therapy. However, many molecular mechanisms and functions of these regulators remain unclear.
合写作者：F. L., L.; Yu, D.; Wang, X. N.; Su, Wu
论文类型：基础研究
学科门类：临床医学
文献类型：J
期号：2014, 23 (2),
页面范围：122-33
是否译文：否