喻风雷

教授 博士生导师 硕士生导师

入职时间:1988-07-01

所在单位:中南大学湘雅二医院

职务:胸外科主任;胸外科研究室主任

学历:博士研究生毕业

性别:男

联系方式:0731-85295204

学位:博士学位

主要任职:现任中南大学湘雅二医院胸外科主任、胸外科研究室主任, 中国医师协会胸外科医师分会常务委员, 全国医师定期考核胸外科专业委员会委员, 中国医师协会住院医师规范化培训外科(胸心外科方向)专业委员会委员; 湖南省医学会胸外科学专业委员会主任委员, 湖南省抗癌协会肺癌专业委员会副主任委员,“十二五”普通高等教育本科国家级规划教材《外科学》第3版 编委。

毕业院校:湖南医科大学

学科:临床医学

当前位置: 中文主页 >> 论文成果

Roles of the hepcidin-ferroportin axis and iron in cancer

发布时间:2016-04-25

点击次数:

发表刊物:European journal of cancer prevention

摘要:Hepcidin is a low-molecular-weight hepatic peptide that regulates iron homeostasis, and acts by causing the degradation of its receptor, the cellular iron exporter ferroportin. On the basis of the major role of the hepcidin-ferroportin axis in iron regulation, recently several studies have discussed its expression and influence on the development and prognosis of cancer. Iron plays a pivotal role in homeostasis. However, insights into the mechanisms of normal iron regulation have provided a new perspective on the basic mechanisms, biological rationale, and pathophysiologic implications of

备注:changes in iron metabolism in cancer. Besides being a crucial stimulus for cancer, iron dysfunction also causes cancer-related anemia. In this review, we discuss aspects of the hepcidin-ferroportin axis and iron regulation, as well as the inherent connections between them in cancer. We also attempt to consider the possibility in theory of novel targets for further individualized therapy. However, many molecular mechanisms and functions of these regulators remain unclear.

合写作者:F. L., L.; Yu, D.; Wang, X. N.; Su, Wu

论文类型:基础研究

学科门类:临床医学

文献类型:J

期号:2014, 23 (2),

页面范围:122-33

是否译文:

上一条: Aorto-azygous fistula complicated by arteriovenous aneurysm treated with video-assisted thoracic surgery

下一条: Regulation of cellular iron metabolism and its implications in lung cancer progression