mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice.

Release time:2016-05-23

Affiliation of Author(s):Central South University

Teaching and Research Group:Department of Endocrinology

Journal:Metab Brain Dis.

Funded by:the National Natural Science Foundation of China (No. 81170754 and 81373394)

Key Words:mTOR . Cognitive deficit . Diabetic . Rapamycin . Tau

Abstract:Abstract Abnormal levels of mammalian target of rapamycin (mTOR) signaling have been recently implicated in the pathophysiology of neurodegenerative diseases, such as Alzheimer's disease (AD). However, the implication of mTOR in diabetes mellitus (DM)-related cognitive dysfunction still remains unknown. In the present study, we found that phosphorylated mTOR at Ser2448, phosphorylated p70S6K at Thr421/Ser424 and phosphorylated tau at Ser396 were significantly increased in the hippocampus of streptozotocin (STZ)-induced diabetic mice when compared with control mice. A low dose of rapamycin ……

Indexed by:Unit Twenty Basic Research

Document Code:doi: 10.1007/s11011-014-9528-1

Discipline:基础医学

Volume:29

Issue:3

Page Number:729-36.

ISSN No.:doi: 10.1007/s11011-014-9528-1

Translation or Not:no

Date of Publication:2014-03-30

Links to published journals:http://www.ncbi.nlm.nih.gov/pubmed/?term=mTOR-mediated+hyperphosphorylation+of+tau+in+the+hippocampus+is+involved+in+cognitive+deficits+in+streptozotocin-induced+diabetic+mice.